Legal Opiates & Opiate Alternatives


A lot of people are looking for an alternative to Oxycontin and the like, owing to the addictive quality of such substances. In this, the age of Krokodil and Carfentanil, when people are turning into lizards or straight up dropping dead from harmful heroin additives like Fentanyl analogues, countless opiate users are looking for other, safer options.

Fortunately for them, there are plenty of options out there. Research suggests that the following are some of the strongest legal opiates available on the current market. We urge our readers to do independent research before taking any of the following compounds.

Elsewhere on this list, you will find some viable opiate alternatives that come from the earth and are known to have far less potential for side effects or addiction.


Said to be 10,000 times more potent than morphine, W-18 ain't nothin' to f**k with! In other words, this one takes the cake when it comes to powerful legal opiates. Unlike other opiates on this list, W-18 is a synthetic opiate that is not considered safe.

In fact, W-18 occupies the number one spot on this list for one reason and one reason only—so that we can warn people against using it. In 2015 alone, there were nearly 300 Fentanyl-related deaths in Canada due to the use of pills that contained W-18.


A potent narcotic analgesic, BDPC was first developed in the 1970's. Today, it is being used by many an alternative to opioids with one Reddit user calling it “frat boy heroin.”

One user on the Bluelight forums reported serious opiate withdrawal relief from taking Bromadol. “I cant tell you all how happy I was to have all withdrawal symptoms completely alleviated,” he wrote. “No more running nose, watering eyes, nuasea [sic], aching knees, etc.”

Some have even said that it doesn't get them high but makes them feel normal. Initial studies have also suggested that, like W-18, BDPC is 10,000 times more potent than morphine.


O-Desmethyltramadol is readily available from Sigma-Aldrich. Similar in nature to other designer drugs, O-DSMT is a synthetic pain killer that is generally considered to be less addictive than other legal opiates.


Quite possibly the safest option on this list, Mitragyna speciosa (kratom) is an all natural pain reliever that acts on the kappa-opioid receptors much like opiates do. Whereas traditional opiates cause respiratory depression, kratom comes with minimal side effects, making it the ideal alternative to legal opiates.

More and more suffering from chronic pain are discovering this “miracle herb,” and it's interesting to note that this folk medicine has been in use for thousands of years throughout the world.


Less potent than some of the other legal opiates on this list, Herkinorin is believed to be 100 times more powerful than morphine. An analogue of the all natural Salvinorum A, Herkinorin is the first mu-selective ligand.

Said to have “unusual properties,” it is believed to present little to no tolerance. For those seeking a more organic option, salvia divinorum is quite similar to herkinorin and offers the same dysphoric and psychoactive effects.


Commonly referred to as “pink,” U-47700 is another legal opiate and one that belongs in the same class as number one on this list as it is extremely dangerous.

Imported from China, “Pink” is usually taken intravenously like heroin and morphine. Users report minor motor coordination impairment, but largely praise the drug for offering no serious side effects or withdrawal symptoms.


Otherwise known as dihydromorphone and marketed as Dilaudid, Hydromorphone has a half-life of 3 hours and can be taken orally or intranasally. Considered stronger than oxycodone, Hydromorphone is typically prescribed to treat post-op pain, broken bones and cancer.

Alas, this one is similar to morphine and heroin in that it can cause acute respiratory distress. For those seeking a safer alternative, refer to kratom above and our informative blog post on natural pain relievers.


Corticosteroids are being used by many doctors to treat neuropathic pain. These include Prednisone and Prednisolone. They reduce inflammation and help manage the symptoms of conditions such as Arthritis.

Others have used corticosteroids to relieve lower back pain and more. A popular pain management program, corticosteroids are said to be able to reverse pain whereas opiates just mask your pain.


Neurostimulators are now being used to prevent pain signals from being activated. Unlike prescrition meds which can relieve pain but cause serious side effects and tolerance, neurostimulation goes right to the source of our pain, eliminating everything from injury-related ailments and headaches.


This one is still being researched to determine its precise medicinal value, but early evidence suggests that it might possess more efficacy than morphine when it comes to long-lasting pain relief.

Studies show that it presents less likelihood of addiction compared to morphine as it doesn't activate the brain's reward system. Perhaps most interesting of all, PZM21 does not appear to come with any serious adverse effects.


As with all substances we discuss on Kratom Krazy, these herbs and synthetic drugs should be carefully vetted before readers consider using them to treat their pain. Be safe, be smart and be well.

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