Agmatine and Kratom: A Comprehensive Guide to This Combination

December 13, 2019 Agmatine, Articles, Kratom Alkaloids, Kratom Blends, Kratom Potentiators, Kratom Products, Kratom Research, Kratom Strains, Supplements

Whether you’re looking to put some spring in your step or get your groove back, there are many ethnobotanicals that can help you get where you’re going. Kratom and Agmatine are two compounds that are said to produce sprightliness and rejuvenation.

Kratom comes from the Ayurvedic herb Mitragyna speciosa, an evergreen tree from the coffee family of plants. It is a potent natural stimulant with inherent heterogeneity. Boasting a variety of indole alkaloids such as mitragynine, 7-hydroxymitragynine and speciociliatine, kratom serves as a multifaceted substance with an indeterminate number of applications.

Like other substances, kratom’s results can be augmented by other materials which affect the CNS (Central Nervous System). As we’ve covered in the past, there are lots of kratom potentiators, the likes of which include turmeric powder, natural fruit juices and more.

One such agitator is Agmatine, a l-arginine derivative that was first uncovered in the early 20th century. Agmatine, otherwise known as guanidine, is often sold in powder or supplement form. It has gained popularity among athletes as a metabolic formula and is often sold in sports shops and vitamin stores.

Those who are into endurance sports dose with Agmatine for enhanced agility and motivation. Together with kratom, it has been stacked for optimal performance.

Agmatine is an investigational drug and is often used for experimentation. Ostensibly referred to as a nutraceutical, it has found favor among the nootropic community for its purported effects in the areas of blood pressure mediation and testosterone production.

As a supplement, it is believed to ameleriorate kidney functioning and inflammation. It is also said to increase insulin secretion. Users like to take Agmatine before hitting the gym because of its natural ability to promote blood flow and muscle growth. This is in addition to its increase in testosterone levels and LH.

For those who don’t know LH stands for the luteinizing hormone that is manufactured by the human pituitary gland. This hormone is associated with sexual development and healthy sexual function. Agmatine’s effect on LH levels should be of interest to both men and women as it assists in controlling one’s menstrual cycle.


As I mentioned earlier, Agmatine is a metabolite of L-arginine, an amino acid. It occurs naturally in our bodies, particularly in our guts where it is produced in the highest concentrations. Agmatine was discovered in 1910 by Albrecht Kossel, the Nobel Prize-winning German biochemist who blazed a trail in genetics.

Kossel first observed Agmatine in herring roe and developed a ground-breaking technique for preparing it. Kossel’s work with Agmatine has been the basis for all future synthesis and study of this unique chemical compound.


As we’ve seen, Agmatine can be beneficial in a number of different areas including exercise, blood circulation, muscle building and hormone levels. But these are but a few of the physiological effects that have been observed in clinical studies.

The following is a list of Agmatine’s various potential effects:

  • Mild heart rate reduction
  • Lowering of blood pressure
  • Oxidative stress reduction
  • Enhancement of glomerular filtration rate
  • Moderate analgesia
  • Anxiety relief
  • Improved stamina

According to a study that was published by the U.S. National Institute of Health, lab rats who were administered Agmatine in conjunction with morphine displayed a reduction in morphine dependence.

It is important to note that there is limited scientific research to support any claims about Agmatine’s purported health benefits. Here in the U.S., this substance is not approved for medicinal use by the FDA (Food & Drug Administration).


Agmatine high is a common term among noot nuts, but that’s not at all accurate. On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right.

Agmatine Sulfate is readily available in capsule and powder form. The so-called “Superhero Supplement” has been embraced by the same students and athletes with whom substances like 5-HTP and Noopept found favor.

Those familiar with the nootropic community will recognize Agmatine as a “study drug,” one that is taken for its cognitive enhancement. Although there is inconsistent evidence to support the theory that it is useful in this regard, that hasn’t stopped individuals from taking 250 grams or more at a time.

The Agmatine Kratom combination is fashionable because Kratom may potentiate Agmatine’s anxiolytic and analgesic effects. The same may be true of Agmatine potentiating Kratom’s aroma.


A select number of documented megadose cases have been documented, but countless individuals have reported their experiences with taking large Agmatine dosages. Fitness enthusiasts have talked about the clean energy boost that serves as a bonus to the maximum muscle pumps that large doses can yield.

Agmatine dosages range from 250 mg to 1,000 mg per scoop with intake recommendations of 1-2 grams daily. However, one study showed that far greater dosages were shown to be safe and effective. Said study consisted of 2.67 grams of Agmatine in capsule form being administered daily in increments of 445 mg.

The results of the study demonstrated that this high dosage could be consumed for a minimum of five years without any signs of deleterious or undesirable effects. These same results pointed to Agmatine’s value as a nutraceutical.


When taken in tandem, these two powerful compounds will likely amplify the others’ effects. This may be advantageous to some, but it could be detrimental to others. Since kratom has been found to potentially disrupt the healthy functioning of the heart and increase blood pressure, it may counteract the positive effects of Agmatine.

The more stimulating kratom strains such as White Borneo and Super Green Malay may negatively affect those with preexisting conditions like high BP or a history of heart disease. Taking kratom in concert with Agmatine may minimize the potential of adverse effects…or it may intensify such effects.

Since there is not enough clinical evidence to corroborate any of these substances’ alleged benefits, it is advisable to take them with caution. Those who have taken the Agmatine/Kratom combination in moderation report a positive experience that was largely free of side effects.

This mixture is said to potentiate the following benefits of the amino acid derivative:

  • Enhanced energy
  • Endurance
  • Improved mood
  • Increased stamina


Whenever you are stacking with two or more supplements it is imperative that you work out the dosage that’s right for you. This usually entails a fair amount of trial and error before you get acclimated to each substance.

One should always start with the lowest dosage possible before slowly graduating to a larger dose. It is also wise to “cycle” dosages; skipping these compounds for a few days in between each dosage is a viable way to avoid tolerance, addiction or abuse. It is also a method by which you are more likely to eliminate the possibility of negative side effects cropping up.

Obviously, we all want to get the best out of our desired supplements. This is true of Kratom as much as it is any other chemical compound. By minimizing your dosages, graduating slowly and taking a break here and there, you will get the most out of your stack.

This is also a good way to rotate your stash. For instance, you can dose with Agmatine and Green Malay on Monday and Tuesday, take Wednesday and Thursday off then follow up with Agmatine and White Vein Sumatra on Friday and Saturday. In this way, you’ll experience all of the unique properties of each kratom strain.

Once you’ve found your sweet spot in terms of dosage level, you should be sure to stick to it. Exceeding this dosage may result in tolerance or adverse reactions.


While it is not a bright idea to take large dosages of both Kratom and Agmatine together, it isn’t out of the ordinary to find users who take moderate dosages of Agmatine to wind back the clock, so to speak. Many who have suffered from Kratom tolerance found that adding Agmatine to their daily regimen reduced their tolerance.

One user who felt like a slave to Kratom after chronic long-term use found that Agmatine was able to reinvigorate his life. As he put it, “I’d reached the point where I could no longer enjoy everything I’d always loved about Kratom, but at the same time I couldn’t live without it.

“When my friend suggested I take an Agmatine supplement to reduce my tolerance I didn’t have much faith. But it worked and I can’t begin to explain what a greeat feeling it was. I was able to sleep better, I was no longer stressed and my mood improved within days….Anyone who needs to feel like Kratom is new again should take the leap of faith and try this out. It worked for me and I thought nothing would.”


The substances referenced above are research chemicals and, as such, they should be administered with great caution. Those who are considering an Agmatine + Kratom mix should consult with their physician prior to taking their first dosage.

If you have a preexisting medical condition, it is best to avoid such a combination. Pregnant and lactating mothers should not take Kratom, nor should they stack without seeking medical advice.

With all of that said, it is this writer’s belief that Agmatine and Kratom are largely safe when taken responsibly and with proper supervision. Again, always consider your own personal sensitivities and needs before stacking with kratom potentiators. Be safe, be smart and be well.

Bob Freville
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