Mixing Kratom and Weed: Safety, Effects & Interactions

June 14, 2020 Articles, Kratom Alkaloids, Kratom Capsules, Kratom Products, Kratom Research, Kratom Reviews, Kratom Strains, Kratom Tea, Kratom Vendors

Cannabis has been in recreational use for ages, but not everyone understands its value as a medicinal aid. An increasing number of states are legalizing the use of medical marijuana due to its efficacy in treating a host of health conditions.

Of course, not everyone is familiar with the chemical make-up of the cannabis plant. That is why it has long been laughed off in the mainstream media as the drug of losers and dropouts. This unfortunate stigmatization is beginning to change thanks to growing availability and scholarly accounts of its benefits.

Similarly, kratom is derived from an evergreen tree belonging to the coffee family of plants. The leaves of this plant have been historically chewed or brewed to induce positive feelings, reduction of fatigue and sensations of invigoration.

Independently, these two substances serve as potentially viable herbal alternatives to harder drugs and each may be advantageous to a wide cross-section of Americans. But whether they work well in combination is another question entirely.

As a lifelong marijuana advocate and born again “biak-biak” fanatic, I had to know whether these two paired well together. The results of my investigation were as pleasing as one could hope for, but prick up your ears because there’s a lot of ground to cover with this cannabis and kratom combo.


It should be stressed upfront that taking any potent substance in concert with another potent substance can result in some adverse effects. If you’re anything like me, you may be prone to anxiety and depression. In that case, you’ll want to be sure that you are mixing kratom and weed appropriately.

For those who suffer from anxiety or work-related stress, mixing kratom and weed can be hazardous in the wrong combination. In other words, you don’t want to take the wrong strains at the wrong time.

In my personal experience, I’ve found that I am most sensitive to cannabis strains that are sativa-dominant. Popular sativa-dominant strains include Amnesia Haze, Bruce Banner, Ghost Train Haze, Green Crack, Sour Diesel and Trainwreck.

Sativa strains have a tendency of instilling panic attacks and paranoia in folks with a history of emotional problems or chronic anxiety disorders. While this isn’t always a problem for users, it is worth bearing in mind when purchasing cannabis.

When it came time to experiment with kratom and weed, I was sure to select a strong indica-dominant cannabis strain. Indica strains contain strong anxiolytic properties which keep the panic attacks and heart palpitations at bay.

Selection is every bit as important when you buy kratom as it is when you pick out cannabis. Kratom strains come in a variety of vein colors including green, red and white. These vein colors are a good indicator of the strain’s effects.

As I mentioned in my strains guide, the best cultivars for anxiety seem to be green veins. Green vein kratom powder is deeply restorative, offering hours of motivation, attentiveness, positive vibes and possible exhilaration.

This combination will yield varying degrees of tranquility, pain relief, stress reduction and so forth. Users may be amazed by the sheer variety of potential benefits.


For the purposes of my inquiry into mixing kratom and weed, I was sure to brew Super Green Malay—my go-to green kratom strain—prior to using my indica-dominant cannabis. I brewed 3 grams even though I would normally brew 3.5 to 4 grams.


Moderation. I find that it is always advisable to take small and responsible dosages of kratom when combining it with other compounds.

After finishing my brew, I waited approximately 10 minutes for it to kick in before unwrapping my Symmetry 1:1 Distillate Vape Cartridge from NY’s The Botanist. Symmetry is a smooth, relaxing strain containing 210 mg of THC and 210 mg of CBD.

I took one puff per the product’s instructions approximately one hour after drinking my kratom tea. Then I waited for a proper amount of time before taking a second puff off my Silo vape pen. In the interest of managing readers’ expectations, I will just say that the effects were more than a little surprising.

The nausea typical of ingesting kratom was no longer an issue with the addition of medical cannabis. Alternately, the headache I sometimes get from smoking weed dissipated entirely with the application of kratom tea.

In summary, mixing kratom and weed can produce an improve state of mind and a full body sensation of warmth, resulting in hours of calm, good humor and general well-being.

It behooves me to mention that dosage is vital to the experience you will have when taking this mixture. The correct lratom dosage for first-time users falls somewhere between a threshold dose of 1.5 grams and a low dosage of 2 to 2.5 grams.


For many seasoned users there might be an insatiable urge to overdo it, but I urge readers against going hard in the beginning. If you’re someone who is used to smoking a blunt to the face that doesn’t necessarily mean that you should do so when combining weed with kratom.

Each of these compounds contains a wide range of chemical properties, many of which can be rather overwhelming in larger dosages. Both kratom and weed are psychoactive substances and as such, they may cause anxiety, agitation, confusion or hallucinations if they are abused.

The THC in cannabis might compliment small doses of kratom, but the alkaloids present in the latter—mitragynine, 7-hydroxymitragynine, etc.—will potentiate THC’s effects. When taken incorrectly, this might result in the dreaded “couch-lock effect.”

Side effects of mixing kratom and weed include dizziness, lethargy, fatigue, drowsiness and brain fog. Although these side effects are not very common, no conclusive scientific data exists about its application.


The marijuana or cannabis plant is rich in terpenes. Terpenes are aromatic oils that induce a plethora of physiological effects. Examples of cannabis terpenes include linalool, limonene and myrcene.

Linalool is largely responsible for the calming aroma of cannabis while limonene is a citrusy compound in the cannabis flower’s resin glands. Limonene has been used in the treatment of obesity, bronchitis and more.

Myrcene is an alkene hydrocarbon that possesses sedative and euphoric properties. It is this terpene which is commonly associated with the couch lock effect. At high concentrations, myrcene may result in drowsiness, fatigue or loss of motor coordination.


The alkaloid profile of kratom varies from strain to strain. In the case of Super Green Malay, mitragynine and 7-hydroxymitragynine both occur at moderate concentrations. These indole alkaloids are linked to kratom’s puissant aroma and sensations of serenity.

All told, kratom contains more than 25 unique alkaloid compounds including corynoxine, paynantheine and mitraphylline. The most prominent is arguably 7-hydroxymitragynine, the terpenoid indole alkaloid that’s known for being relieving and tranquil in nature.


Both of these compounds have been used by a wide array of individuals, many of whom suffer from chronic pain, anxiety or fibromyalgia. Personally, I have brewed kratom whenever I’ve experienced lower back pain or joint inflammation.

While kratom is not to be confused with a form of medical treatment, it is undeniably fashionable among folks afflicted with chronic conditions. Athletes and gym rats have found kratom to be a rad pre-workout concoction while recreational users have embraced it for its sociability and tranquility.

Similarly, cannabis smokers have espoused the herb for its CBD-driven analgesia and THC-driven calm. Both of these compounds have put a smile on the faces of thousands upon thousands of users.


As I mentioned earlier, cannabis is powered by a range of terpenes whereas kratom draws its potency from a number of alkaloids. Although these substances are nearly identical in many ways, they should not be confused with one another.

Weed is deeply psychoactive whereas kratom is only mildly psychoactive. Even though there is a relative dearth of scientific information about kratom’s mechanism of action, it is historically considered to be a folk medicine by the natives of Southeast Asia.

By contrast, cannabis was not always regarded as an edible substance and was, in fact, used to produce fuel and textiles.


Yes, smoking a sensible amount of medical cannabis after brewing a small cup of kratom tea is relatively safe. As with all chemicals, they should be consumed in moderate dosages.

It is important to note that kratom is not approved for medicinal use by the FDA. Kratom powder and kratom capsules are offered strictly for research purposes only.

Chronic kratom use has been linked to tolerance, addiction, abuse and overdose. Those who brew kratom in mass quantities put themselves at serious health risk, as kratom may lead to liver damage, increased heart rate, respiratory depression, kidney damage or even liver failure.

I think you’ll agree that it only makes sense to take small amounts of each. After all, you’re mixing them up to feel good, not to end up in an emergency room at your neighborhood hospital.


If you suffer from a preexisting health condition, your physician may have you on any number of prescription medications. Should you decide to mixing kratom and weed, you’ll want to consult with a medical professional before doing so.

Cannabis alone has no fewer than 376 known drugs interactions which include Ativan, Benadryl, Klonopin, Tramadol and Tylenol.

What’s more, combining kratom with any other drug, whether it’s an OTC medication such as Loperamide or prescription opiates, is never prudent. As an herbal depressant, kratom tea can be dangerous when taken in concert with other depressants such as alcohol, opiates or certain over-the-counter allergy pills.


Over time our attitudes towards these two respective plants have changed and, no doubt, they will continue to. As more information becomes available, it is imperative that vendors share this knowledge with the public.

By encouraging education and fostering a dialogue about kratom and weed, we can finally remove these incredible herbs from the shackles of their well-worn mythologies. Be safe, be smart and be well.

Bob Freville
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